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Science Wednesday: Tox21’s 10,000 Compound List

Wednesday, December 14th, 2011


Each week we write about the science behind environmental protection.Previous Science Wednesdays.

By Aaron Ferster

I’m a big fan of those “Top Ten” lists that come out at the end of every year. I like to track how many of my favorite movie critic’s Top Ten List of Films I’ve caught during the year (so far, I’ve seen most of them—and I’ve still got a couple of weeks to go before New Year’s Eve). The synopses included in the lists of Top Ten Best Novels of the year let me feel like I’m in the know about the latest literature, even though I’ve clearly spent more time at the cinema than at the bookstore.

But this year the most impressive “list” I’ve come across came out last week, when EPA and its partners from the National Institutes of Health and the U.S. Food and Drug Administration announced the compounds to be tested as part of the collaborative Tox21 research program over the next couple of years

Only the list is slightly more robust than ten—it’s a 10,000 compound library.

The library contains chemicals covering a wide variety of classifications, including chemicals found in industrial processes, consumer products, and food additives, as well as human and veterinary drugs. A large number of reference compounds are also included to give researchers access to different toxicological or disease endpoints, duplicate compounds for evaluating test methods, and a small set of chemical mixtures for a pilot study.

“The Tox21 partnership integrates revolutionary advances in molecular biology, chemistry, and computer science to quickly and cost-effectively screen the thousands of chemicals in use today,” said Paul Anastas, Ph.D., the Assistant Administrator for EPA’s Office of Research and Development.

The compounds will be tested with a high-speed, robotic testing system that was unveiled early this year—the subject of a previous blog post here on Science Wednesday.  That means the tests will continue nearly nonstop, 24-7 until all the compounds have been analyzed.

Results of the tests will provide information useful for evaluating if any of the 10,000 chemicals have the potential to disrupt processes in the human body to an extent that would lead to adverse health effects. I’ll be sure to blog about those results once they start rolling in. But in the meantime, I’ll be at the movies.

About the author: Aaron Ferster is the senior science writer for EPA’s Office of Research and Development, and the editor of Science Wednesday.

Editor’s Note: The opinions expressed in Greenversations are those of the author. They do not reflect EPA policy, endorsement, or action, and EPA does not verify the accuracy or science of the contents of the blog.

Science Wednesday – Apps for the Environment: The New Way of Communicating Science and Information

Wednesday, August 24th, 2011


Each week we write about the science behind environmental protection. Previous Science Wednesdays.
By Jing Zhang

Want to know the weather tomorrow, the next movie showing, or the latest Hollywood gossip? There’s an app for that! In the age of smart phones, answers are literally at your fingertips on your iPhone or Android device. There’s no need to scour the internet for solutions when you can simply download an app that will gather the relevant information for you in a user-friendly application on your phone.

Working in EPA’s Office of Research and Development, I constantly hear of the developments and data that Agency researchers and scientists have produced. These scientists work diligently year around on protecting the environment and human health as outlined in Administrator Lisa P. Jackson’s Seven Priorities. What better way is there for communicating the resources and discoveries of EPA researchers than in an easy-to-use app on your mobile device?

challengebanner_MThe EPA Apps for the Environment Challenge invites software developers to use EPA data to develop apps so the public can understand or protect the environment in their daily lives. Want to know the air quality where you live or which cars have the least amount of greenhouse gas emissions? There could be an app for that!

EPA has a lot of data that is publicly available. This data includes information from the Toxic Release Inventory which tells you facilities that dispose of or release toxic chemicals, real time air quality monitoring, green vehicle guide that gives environmental performance guides for vehicles, a Superfund website, and chemical toxicity information from the ToxCast database. Because these datasets are overwhelming for those with less technical and scientific knowledge like me, EPA held a series of webinars where data owners explained the information.

If you’re like me and don’t know the first thing about developing an app, you can still participate by submitting ideas for apps. These ideas are useful in providing developers and researchers a window of insight into the needs and wants of the public.

For more information and rules, visit the Apps for the Environment website. The deadline for submissions is September 16. In the meantime, you can find out the latest information on Twitter, just search #greenapps.

About the Author: Jing Zhang is a student services contractor working with the science communications team in EPA’s Office of Research and Development.

Editor’s Note: The opinions expressed in Greenversations are those of the author. They do not reflect EPA policy, endorsement, or action, and EPA does not verify the accuracy or science of the contents of the blog.

Science to Decisions from the OSV Bold

Friday, August 12th, 2011


By Jeanethe Falvey

This week, scientists from EPA, Maine Department of Environmental Protection, University of New England, and the Wells National Estuarine Research Reserve completed a water sampling effort along the southern coast of New England. Why?

Many asked when we were in Ipswich Bay off Essex, Massachusetts. We were thrilled that boaters took interest to the big blue ship; cautiously, but curiously approaching when we stopped to send down equipment. During boat to boat conversations from the back deck, they said they had never seen anything like the Bold before. It was a great opportunity to explain firsthand what we were doing, and why we have this research ship. When I said we were sampling water quality along the coastline they asked, “Is it ok for swimming?”

sampler

"OSV Bold uses a CTD (Conductivity, Temperature, Depth) to measure water samples at different depths."

I explained for swimming yes. We were looking for something less obvious, sampling the bottom, middle, and surface depths further offshore compared to estuaries, or bays, more geographically enclosed areas where rivers and streams meet the sea. In this confluence of environments where fresh water sources and land meet the ocean, are there specific indications showing that our land-based activities are having too much of a negative impact in the coastal environment? Too much would mean that the natural environment can’t cope with the influx of pollutants and runoff from land. Examples of this can be algal blooms, or “fish kills.” More obvious to many would be closed beach days due to bacterial pollution in the water, that’s always from our sewage and runoff too.

This is why for the third year, we sampled for nutrients, specifically, phosphorus and nitrogen, and also for chlorophyll (plant matter in the ocean). Nutrients (commonly found in fertilizers, as an example) help plants grow. Excess amounts can cause algal overgrowth and deteriorate natural conditions, sometimes to the point where fish and other sea life cannot survive.

If we see trends from something specific like nutrients, then we hope to better inform decisions made on land: encouraging SmartGrowth and sustainable development, better sewage treatment, or generally raising awareness about more environmentally conscious day to day activities.

The Bold isn’t just an ocean going research vessel, it’s one of our best tools to study our natural world and use that science to inform how we protect our environment.

About the author: Jeanethe Falvey, U.S. EPA Office of External Affairs and Environmental Education, based in Boston, Massachusetts.

Editor’s Note: The opinions expressed in Greenversations are those of the author. They do not reflect EPA policy, endorsement, or action, and EPA does not verify the accuracy or science of the contents of the blog.

Headed Off On Our Ocean Research Ship the Bold!

Friday, August 5th, 2011


I’m not sure why, but getting on this ship always makes me smile. Maybe it’s the familiar faces among the crew that I’m lucky enough to see every so often, the feeling of the ship when it’s underway, or the smell of Amanda’s cooking. Surely it’s a combination, but above all else, I know the underlying reason this beautiful ship makes me so happy – the sheer fact that the U.S. Environmental Protection Agency has it to learn more about our world.

Of all U.S. vessels and ships supporting our missions worldwide, this one of ours isn’t gray, anymore. The OSV Bold is bright blue with a proud green, blue and white sash down the bow. This is no ordinary ship.

Today, ferries full of Boston tourists have passed us and I can’t help but wonder what they’re thinking as we wave back and forth.

Just heard a horn blast from the Coast Guard station; we’re off! The tone is serious, but excited as crew members untie and Captain Jere heads up to the bridge.

It’s all for science. This is all to have a better understanding of the
impacts we’ve had on our oceans and coastal environment.

These impacts aren’t just from activities on the water, they’re mostly from what we do far, far away on land. Rainwater and storm runoff carries pollution from our roads and paved areas to rivers and coasts. That pollution can be found miles offshore. It’s not the most beautiful topic, but our sewage ends up out here too. Treatment helps, but it doesn’t make elements of it disappear.

How much can the environment take? Well it varies.  For a long time, dilution was the solution, but our oceans are only so big. The life they support, which we treasure so deeply, can only take so much.

Today through early Thursday of next week (August 11) follow my updates about our trip. Ask questions here or reply to our tweets while I’ve got the ear of some of our best scientists.

At the very least we hope to give you an idea of why we feel this work is so important.

About the author: Jeanethe Falvey, U.S. EPA Office of External Affairs,
Washington D.C. Based in Boston, Massachusetts.

Science Wednesday: Square Pegs, Round Holes, and Chemical Safety for Sustainability

Wednesday, April 27th, 2011


Each week we write about the science behind environmental protection. Previous Science Wednesdays.

By Jeff Morris, PhD

All our lives we have been cautioned against trying to fit square pegs into round holes. The metaphor itself is constructed to make such an effort seem foolish and just a bit unsavory: forcing the hard edges of a square into the smooth curves of a circle evokes a certain violence and violation of geometric propriety. And the message behind the saying is clear: don’t try to join things that clearly don’t belong together.

However, fitting square pegs into round holes is just what we are doing in EPA’s Office of Research and Development: we are encouraging new collaborations between scientific disciplines to formulate innovative science questions to address chemical safety. We think this is a very good thing, but it does raise questions.

What, for instance, does cultural anthropology have to do with molecular design? Perhaps nothing; or perhaps quite a bit. A cultural anthropologist would be interested in how a society’s institutions shape the tools it creates and how it uses those tools. A chemist or engineer designs a chemical or material object with some intention in mind. (Design implies intent: nobody creates something for no reason). Once designed, how will society use the new chemical or material? Importantly for EPA, will it be used in a way that minimizes impact on, or perhaps even improves, the environment and human well-being? Neither the chemist nor the anthropologist alone can answer these questions. But perhaps the two of them, together with environmental scientists, can. Maybe a fit can be found for a square peg within a round hole.

Finding flex in the square peg/round hole metaphor doesn’t mean forcing fits that don’t make sense. In EPA’s Chemical Safety for Sustainability Research Program, sometimes we will need to just let chemists do their chemistry within their own disciplinary space. However, all the while we can be mindful that sometimes square edges can be rounded off and the walls of circles stretched, and bringing together very different scientific disciplines can lead to the shaping of innovative research questions that take science in new and rewarding directions. Since old ways of working within disciplinary boundaries have not always given us science and technology that has advanced environmental sustainability, perhaps it’s time to not take as given old sayings and metaphors, and see if we can’t fit a few square pegs into round holes.

About the author: Jeff Morris, PhD is the National Program Director for Nanotechnology in EPA’s Office of Research and Development.

Editor’s Note: The opinions expressed in Greenversations are those of the author. They do not reflect EPA policy, endorsement, or action, and EPA does not verify the accuracy or science of the contents of the blog.

Science Wednesday: Need Effective Virus Removal? Try Rust.

Wednesday, April 13th, 2011


Each week we write about the science behind environmental protection. Previous Science Wednesdays.

By Ian Bradley

What if, in addition to earning a degree from a top-ranked engineering program, you could actually change the lives of several million people? With the help of the EPA’s People, Prosperity and the Planet Award (P3), students at the University of Illinois at Urbana-Champaign are doing just that.

For several years, the Mayan community of Socorro, Guatemala was afflicted with acute and chronic gastrointestinal diseases stemming from poor drinking water quality, soil-transmitted helminthes (worm) infections, and malnutrition. These illnesses resulted in missed school, emotional and economic hardship, and in some cases, death.

In an attempt to alleviate this crisis, the people of Socorro assembled a council and, with the help of Wuqu’ Kawoq, a U.S.-based non-governmental organization, contacted the University of Illinois Engineers Without Borders (EWB-UIUC) requesting assistance. As a result of a three-year partnership, relief has come in the form of a simple, effective, and ever-evolving water treatment system: the biosand filter (BSF).

BSFs have been chosen by hundreds of humanitarian groups as the best method for improving water quality in developing countries and, as of 2009, it is estimated that over 300,000 BSFs have been implemented in over 70 countries. Surveys reveal its wide acceptance by users due to the improved appearance, smell, and taste of the treated water. However, research has identified a critical shortcoming: BSFs are not highly effective in removing viruses.

Current research performed at the University of Illinois has shown that the incorporation of iron shavings, a product available commercially across the world, can remove more than 99.999% of viruses in water. The iron rusts, forming positively charged oxides to which negatively charged viruses attach. Because of the water chemistry, the iron doesn’t re-enter the water and the user never tastes the iron in the filtered water. The only end result is cleaner, safer drinking water.

In 2009, students from the University of Illinois completed a P3-supported project to install 120 traditional BSFs in Socorro. Over the next two years, the research is being expanded with the help of partners such as the Universidad del Valle de Guatemala (UVG) to bring iron-amended filters to those in need.

For little cost and effort, currently implemented BSFs could be amended with locally available iron sources, providing a substantially improved barrier against waterborne viruses and, hopefully, bringing relief to millions of people in the process.

See winning projects at the National Sustainable Design Expo, April 16 and 17, 2011 on the National Mall in Washington, DC.

About the author: Ian Bradley is an environmental engineering graduate student at the University of Illinois at Urbana-Champaign. He has been working with EWB-UIUC and The Guatemala Water Project for the last three years.

Editor’s Note: The opinions expressed in Greenversations are those of the author. They do not reflect EPA policy, endorsement, or action, and EPA does not verify the accuracy or science of the contents of the blog.

“Preventing Lead Poisoning”

Monday, October 25th, 2010


Picture this: You live in a gorgeous older row home in Washington D. C. Although it’s a “fixer upper”, you bought it for its unmatched Victorian charm and its unbeatable location (Who doesn’t want to live next to a cupcake shop?). You finally decide it’s time to remodel the kid’s room and update the kitchen, but your spidey-sense is going off because you know that renovating a pre-1978 homes with lead paint can have risks. What’s the next step?

  • Do a search on the internet about EPA’s Lead Renovation, Repair and Painting rule
  • Look for a contractor, but make sure to ask them if they are EPA Lead-Safe Certified
  • Check with your pediatrician about testing your children for lead

The answer is: All of the above — And don’t forget to share what you learn on your neighborhood list serve!

Learning about Lead-Safe renovations is one of the many actions you can take to prevent lead poisoning during Lead Poisoning Prevention Week this October 24-30, 2010.

This year for Lead Poisoning Prevention Week, consider taking concrete steps to make a difference (or tell a neighbor):

  1. Get Your Home Tested. Ask for a lead inspection if you live in home built before 1978.
  2. Get Your Child Tested. Ask your doctor to test your young children for lead even if they seem healthy.
  3. Get the Facts. Read more information about preventing childhood lead poisoning

Tell us, what are you doing to spread the word or learn more about Lead Poisoning Prevention.

About the author: Christina Wadlington joined EPA’s Office of Pollution Prevention and Toxics in July 2008 and works in the National Program Chemicals Division.

Editor’s Note: The opinions expressed in Greenversations are those of the author. They do not reflect EPA policy, endorsement, or action, and EPA does not verify the accuracy or science of the contents of the blog.

Protecting Our Children From Exposure to Lead

Thursday, October 14th, 2010


By Lina Younes

During my youngest daughter’s yearly check up, the nurse asked the traditional lead screening questions regarding possible exposures to lead. “Does my child live in or regularly visit a home, child care or building built before 1950?” “Does my child live or regularly visit a home or child care built before 1978?” “Does my child spend time with anyone that has a job or hobby where they may work with lead?” and several more. Luckily, I was able to answer “no” to all the lead screening questions. However, the questions highlighted the fact that there are multiple possibilities of exposure in addition to lead-based paint.

Childhood lead poisoning remains a major environmental health problem in the United States. Exposure to this toxic metal can harm young children and babies even before they are born. Exposure to high levels of lead can damage the developing brain and nervous system of young children, plus cause serious behavior and learning problems. For years, the main source of lead exposure has been lead-based paint or dust particles from lead-based paint. Although the federal government banned the use of lead in paint in 1978, many homes built before the ban may still have remnants of lead-based paint.

What are some of the other sources of lead? Well, pottery and ceramics made in other countries may have lead. Some folk remedies like greta and azarcón which may be used to treat stomach ailments may also have lead. Furthermore, we’ve also heard of other problems with lead in some imported toys and children’s jewelry.

So, what do you do if you think your child might have been exposed to this toxic metal? Does your child show behavioral problems or developmental problems? The first step to allay your concerns will be to have your child tested for possible lead poisoning. A simple blood test will indicate the course to follow.

During National Lead Poisoning Prevention Week help us to spread the word so we all can protect our children.

About the author: Lina Younes has been working for EPA since 2002 and chairs EPA’s Multilingual Communications Task Force. Prior to joining EPA, she was the Washington bureau chief for two Puerto Rican newspapers and she has worked for several government agencies.

Editor’s Note: The opinions expressed in Greenversations are those of the author. They do not reflect EPA policy, endorsement, or action, and EPA does not verify the accuracy or science of the contents of the blog.

My Property Info

Monday, August 30th, 2010


By Wendy Schumacher

Prior to relocating to Washington in 2007, I had to sell my home in Fort Collins, Colorado. The biggest challenge to marketing the property wasn’t the original1962 kitchen cabinets or the three feet of snow covering the beautiful drought tolerant garden, it was determining if radon was present and, if so, if the level was above acceptable limits.

In many states, sales contracts require that people selling property certify if the property is located in a flood plain or free from a variety of environmental hazards ranging from radon to lead paint. On the other hand, today’s buyers and their lenders want to know more. In fact, a large number of Freedom of Information Act (FOIA) requests submitted to EPA ask for records about a single property someone is considering buying or financing or because some states require certification that EPA does not have any information on the property. The FOIA process gives federal agencies 20 working days to respond. For this type of request, most of the time EPA does not have any record of the requestor’s potential new home or small business. That’s always good news!

To reduce the amount of time for requestors to obtain a response from days to minutes, on June 25, 2010, EPA released a web-based tool where it will be possible to search EPA’s databases for environmental information by an individual address and print it in a single report. The tool is called MyPropertyInfo.

The tool’s primary audience is expected to be real estate agents, mortgage banks and engineering and environmental consulting firms. That said, everyone around the office who has helped with testing this new tool has looked up their own and their Mom’s address, too.

Wouldn’t MyPropertyInfo have been useful during my time as the FOIA Officer in EPA’s Regional Office in Chicago! I’ll never forget being seated at a formal dinner next to a real estate attorney who wanted to know the status of his client’s proposed purchase of a former gas station before we even finished our salads.

About the author: Wendy Schumacher is on detail to the National FOIA Office from the Office of Water. Between assignments in EPA Region 5 and Headquarters, she spent six years with the National Park Service’s Natural Resource Program Center in Fort Collins, Colorado.

Editor’s Note: The opinions expressed in Greenversations are those of the author. They do not reflect EPA policy, endorsement, or action, and EPA does not verify the accuracy or science of the contents of the blog.

Science Wednesday: Innovations in Food Preservation using my Mother’s Nut Jar

Wednesday, August 11th, 2010


Each week we write about the science behind environmental protection. Previous Science Wednesdays.

By Daniel Liss

On Earth Day, I had the privilege of exhibiting my project—an energy efficient approach to food preservation—at EPA’s 6th Annual National Sustainable Design Expo. I was able to preserve food with a practically negligible impact on the environment.

Using my mother’s nut jar and other household equipment, I invented a device for preserving food that employs a promising, inexpensive new technique that could serve as an alternative to modified atmosphere packaging (MAP), the corporate industry standard. MAP involves displacing the air inside a container with either a single gas or mixture of gases to create an atmosphere that slows the deterioration of food.

Rather than displacing air, my device achieves the same objective with a simple chemical reaction. I apply an electrical charge to carbon fiber positioned inside a container, causing the fiber to burn. The surrounding oxygen reacts with the burning carbon to form carbon dioxide within the container.

In short, the existing air inside the container is transformed into a low-oxygen, high-carbon dioxide, atmosphere—hostile to the kinds of bacteria that are most harmful to food.

Although I was only 15 and my prototype was made from a nut jar, I had the opportunity to test my device at the Walter Reed Army Institute of Research, which graciously provided laboratory space and funding after learning about my idea during a summer internship.

Based on my test results, I was able to confirm that my device significantly inhibits bacterial growth and also slows the enzymatic degradation of meat. Even more exciting is that it works with just a few pieces of relatively inexpensive equipment, and unlike vacuum packaging, does not crush food, or suck out volatile ingredients such as fats and oils.

My method essentially replicates the benefits of MAP, without the need for sophisticated equipment or large amounts of pressurized gasses on hand. Most importantly, a package atmosphere only needs to be changed once, reducing the need for additives.

About the Author:  Daniel Liss is a rising junior at the Charles E. Smith Jewish Day School. Since EPA’s Expo, he won a gold medal at the International Environmental Project Olympiad (INEPO), in Istanbul, Turkey. Previously, he had won a bronze medal at the International Sustainable World [Environment, Energy, Engineering] Project Olympiad (I-SWEEEP) in Houston, Texas.

Editor’s Note: The opinions expressed in Greenversations are those of the author. They do not reflect EPA policy, endorsement, or action, and EPA does not verify the accuracy or science of the contents of the blog.